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DEFS-008C
α-Defensin 6
Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge)
Size:1mg
P1(RMB):5450
MW:3708.27
One letter sequence:AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge)
Molecular Formula:C156H228N46O46S7
Description:Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.
Literature Reference:Z.Wu et al., J. Pept. Res., 64, 118 (2004) M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005) E.Hazrati et al., J. Immunol., 177, 8658 (2006) A.Szyk et al., Protein Sci., 15, 2749 (2006) M.E.Klotman et al., J. Immunol., 180, 6176 (2008)
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