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CRFS-003A
Astressin
DPhe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2
Size:0.5mg
P1(RMB):582
MW:3563.2
One letter sequence:fHLLREVLE-Nle-ARAEQLAQ-cyclo(EAHK)NRKL-Nle-EII-NH2
Molecular Formula:C161H269N49O42
Description:A new CRF antagonist (cyclo(30/33) that, when injected into the CSF at low doses (1-10ug), results in antagonistic action against CRF and stress-related alterations of gastrointestinal motor function, without an intrinsic effect in these in vivo systems.
Literature Reference:V. Martinez et al., J. Pharmacol. Exp. Ther., 280(2), 754 (1997)
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