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GALA-001B
Galanin, human
Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser
Size:1.0mg
P1(RMB):828
MW:3157.5
One letter sequence:GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS
Molecular Formula:C139H210N42O43
Description:Human galanin, originally been isolated from colon and pituitary, that activates the rat galanin receptor and inhibits acetylcholine release, glutamate release and carbachol-stimulated phosphatidylinositol hydrolysis in the hippocampus. Recent studies indicated that galanin is also linked to behavioral and cognitive deficits in Alzheimer's disease.
Literature Reference:W.E. Schmidt et al., PNAS, 88, 11435 (1991)
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