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PANP-008A
Insulin B (9 - 23)
Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly
Size:1mg
P1(RMB):340
MW:1645.9
One letter sequence:SHLVEALYLVCGERG
Molecular Formula:C72H116N20O22S
Description: This insulin B-chain peptide binds to a MHC-II allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Literature Reference:Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
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