CPC Scientific Citation
Multimodal endoscope can quantify wide-field fluorescence detection of Barrett’s neoplasia
Bishnu P. Joshi, Xiyu Duan, Richard S. Kwon, Cyrus Piraka, B. Joseph Elmunzer, Shaoying Lu, Emily F. Rabinsky, David G. Beer, Henry D. Appelman, Scott R. Owens, Rork Kuick, Nobuyuki Doguchi, D. Kim Turgeon, Thomas D. Wang
Joshi, Bishnu P., et al. "Multimodal endoscope can quantify wide-field fluorescence detection of Barrett’s neoplasia." Endoscopy 48.02 (2016): A1-A13.
was synthesized using good manufacturing practice (GMP) methods (CPC Scientific, Inc.). Stability was evaluated on high-performance liquid chromatography (HPLC) and mass spectrometry. Aliquots of peptide (0.8 mg) were stored at −20 °C as lyophilized powder in single-use amber vials for protection from light.
Hpv e6 protein t cell epitopes and uses thereof
Nakagawa, Mayumi. "Hpv e6 protein t cell epitopes and uses thereof." U.S. Patent Application No. 14/566,604.
To define the minimal and optimal amino acids sequences of the CD8 T-cell epitope, 8-mer, 10-mer, 11-mer, and homologous peptides were synthesized (CPC Scientific, Inc, San Jose, Calif.). All peptides were dissolved in small amounts of dimethylsulfoxide (˜50 μl), diluted to 5 mM with phosphate buffered saline, and kept frozen at −80° C. until final dilution for their use in the assay... Commercially produced cGMP-grade peptides (90% purity; CPC Scientific, San Jose, Calif.) is examined. Their safety for human use is ensured, in accordance with FDA requirements, by testing 14-day sterility (USP )...
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant
Rebecca Saenz, Diahnn Futalan, Lien Leutenez, Fien Eekhout, Jessie F Fecteau, Simeon Sundelius, Stig Sundqvist, Marie Larsson, Tomoko Hayashi, Boris Minev, Dennis Carson, Sadik Esener, Bradley Messmer, and Davorka Messmer
Saenz, Rebecca, et al. "TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant." J Transl Med 12 (2014): 211.
The peptides, including Hp91 (DPNAPKRPPSAFFLFCSE), Hp121 (SIGDVAKKLGEMWNNTAA), scrambled Hp91 (ASLAPPFPNCFDPKSREF), and OVA-I (SIINFEKL) were all synthesized at GMP facilities by GenScript Corp (Piscataway, NJ, USA) and CPC Scientific (San Jose, CA, USA). Peptides were synthesized with an N-terminal biotin, acetyl, or fluorescent tag (Cp488) as indicated in the figure legends. Peptides were routinely synthesized with greater than 95% purity.
Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results
Matthew B. Sturm, Bishnu P. Joshi, Shaoying Lu, Cyrus Piraka, Supang Khondee, Badih Joseph Elmunzer, Richard S. Kwon, David G. Beer, Henry D. Appelman, Danielle Kim Turgeon and Thomas D. Wang
Sturm, Matthew B., et al. "Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results." Science Translational Medicine 5.184 (2013): 184ra61-184ra61.
For the clinical and pharmacology/toxicology studies, ASY*-FITC was GMP synthesized (CPC Scientific). Stability was evaluated by appearance (color), HPLC, and mass spectrometry for 3 years. The pharmacology/toxicology study in rats was conducted in accordance with FDA CFR title 21, part 58...
Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine
Xuelian Wang, Hannah N. Coleman, Uma Nagarajan, Horace J. Spencer, Mayumi Nakagawa
Wang, Xuelian, et al. "Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine." Vaccine 31.49 (2013): 5806-5813.